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目的:探讨宫颈癌及癌前病变发病的相关危险因素,为防治该病提供相关资料。方法:以在应城市人民医院确诊的68例宫颈癌及癌前病变患者为病例组,选择同时期健康体检的70例非宫颈癌女性为对照组,收集两组资料进行病例-对照研究。结果:宫颈癌及癌前病变发病的相关危险因素包括:HPV感染(OR=19.784,P=0.000)、性传播疾病史(STD,非HPV)(OR=15.608,P=0.000)、工作压力大(OR=7.722,P=0.009)、吸烟史(OR=3.621,P=0.031)等,而盆腔炎、流产史、分娩史等并没有增加宫颈癌及癌前病变的发病率(P>0.05)。结论:HPV感染、性传播疾病史(非HPV)、工作压力大、吸烟史等因素可增加宫颈癌及癌前病变的发病率,积极控制相关危险因素有助于预防宫颈癌及癌前病变的发生。
Objective: To investigate the related risk factors of cervical cancer and precancerous lesions and provide relevant information for the prevention and treatment of the disease. Methods: Sixty-eight cases of cervical cancer and precancerous lesions diagnosed in Yingcheng People’s Hospital were selected as the case group and 70 healthy non-cervical cancer women in the same period were selected as the control group. Two groups of data were collected for case-control study. Results: The risk factors of cervical cancer and precancerous lesions were HPV infection (OR = 19.784, P = 0.000), history of sexually transmitted diseases (STD, non HPV) (OR = 15.608, P = 0.000) (OR = 7.722, P = 0.009) and smoking history (OR = 3.621, P = 0.031). The incidence of cervical cancer and precancerous lesion did not increase in patients with pelvic inflammatory disease, abortion history, delivery history, . CONCLUSIONS: HPV infection, history of sexually transmitted diseases (non-HPV), stressful work, smoking history and other factors can increase the incidence of cervical cancer and precancerous lesions. Active control of related risk factors may help prevent cervical cancer and precancerous lesions occur.