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破伤风免疫球蛋白是从具有高水平破伤风抗体的献浆者采集血浆制得。通常是在接受一疗程破伤风免疫治疗后,或外伤后作了一次破伤风免疫注射后即选作献浆者。然而用这种方法征集献浆者是不能完全令人满意的,因为不是所有献浆者在免疫后都达到合适的抗体水平(大于10IU/ml)。为此,作者研究了两种破伤风疫苗的效果对比,最适于作破伤风超免疫的献浆者的条件和适合作单采血浆的抗体水平持续时间。
Tetanus immunoglobulins are obtained from plasma donors who have high levels of tetanus antibodies. Usually after receiving a course of immunotherapy for tetanus, or after a tetanus immunization after injury was selected as the donor. However, it is not entirely satisfactory to solicit donors in this way, as not all donors reach the appropriate antibody level (greater than 10 IU / ml) after immunization. To this end, the authors studied the effects of two types of tetanus vaccines, the most appropriate conditions for plasma donors for tetanus hyperimmune and the duration of antibodies suitable for apheresis.