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本文的目的是复习目前对合用抗菌药物的意见,多种抗菌药合用的缺陷以及新抗菌药的临床应用问题。与儿科特别有关的是新药增效新明磺(SMZ+TMP,即磺胺甲基异恶唑+抗菌增效剂)以及青霉素类与氨基糖甙类的合用。合用抗菌药的理由有:1.增强抗菌幅度;2.治疗混合感染;3.延迟细菌发生耐药;4.减少每种药物用量而降低毒性;5.预防二重感染;6.根除顽固细菌或L型细菌(译者注:L型菌为细菌的细胞壁被破坏后,在生长中形成的一种独特菌落,与支原体类似。);7.可产生协同作用。但是,合用抗菌药有以下弊病:1.增加毒性及副作用;2.产生化学或物理方面的配伍禁忌;3.增加经
The purpose of this article is to review the current views on the combination of antimicrobials, defects in the combination of multiple antimicrobials, and clinical application of new antimicrobials. Of particular relevance to pediatrics is the synergistic combination of neostigmine (SMZ + TMP, sulfamethoxazole + antibacterial synergist) and penicillins with aminoglycosides. The reasons for the combination of antimicrobial agents are: 1. To enhance the antimicrobial amplitude; 2. To treat mixed infections; 3. To delay bacterial resistance; 4. To reduce the amount of each drug to reduce toxicity; 5. To prevent double infection; 6. Eradication of stubborn bacteria Or L-type bacteria (Translator’s Note: L-type bacteria is the bacterial cell wall is destroyed, the formation of a unique colony growth, similar to mycoplasma); 7. Can produce synergies. However, the combined use of antimicrobial drugs have the following drawbacks: 1. To increase the toxicity and side effects; 2. To produce chemical or physical incompatibility; 3. To increase by the