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本文主要介绍新近开发的透皮及各种粘膜(不包括胃肠道粘膜)吸收的制剂。一、透皮吸收制剂 1.由膜渗透控制的给药系统它是由含有固态或混悬液的药物贮库和控释膜组成的零级释药的给药系统。如Alza公司的Transderm V以及了ransderm Nitro。前者为抗晕动药东茛菪碱制剂,每小时释放主药10μg,持续72小时。Transderm Nitro是预防心绞痛的硝酸甘油制剂,释药速率为50μg/cm~2/h,可连续释放24小时;表面积为20cm~2,敷贴左胸部,可维持0.21
This article focuses on the newly developed transdermal and mucosal (excluding gastrointestinal mucosa) absorption of the preparation. I. Transdermal absorption preparation 1. Administration system controlled by membrane osmosis It is a zero-level drug delivery system consisting of a drug reservoir containing a solid or suspension and a controlled-release membrane. Such as Alza’s Transderm V and ransderm Nitro. The former is an antiswelling agent scopolamine preparation, release of 10μg per hour for 72 hours. Transderm Nitro is a nitroglycerin prophylaxis for angina pectoris with a release rate of 50μg / cm ~ 2 / h, which can be continuously released for 24 hours. The surface area is 20cm ~ 2 and the left chest is applied with 0.21