STAT3信号传导通路接受细胞外信号刺激,作用于细胞核内特异的DNA片段,调控靶基因的转录,直接影响细胞的增殖分化和凋亡。STAT3蛋白异常激活与多种恶性肿瘤的发生发展密切相关,以STAT3为靶点的肿瘤治疗已取得了初步成果。本文就STAT3 蛋白与非小细胞肺癌关系的研究进展作一综述。 The STAT3 signal transduction pathway is stimulated by extracellular signals, acts on specific DNA fragments in the nucleus, regulates the transcription of the target genes, and directly influences cell proliferation, differentiation, and apoptosis. The abnormal activation of STAT3 protein is closely related to the occurrence and development of a variety of malignant tumors. Preliminary results have been achieved in the treatment of tumors targeting STAT3. This article reviews the research progress of the relationship between STAT3 protein and non-small cell lung cancer.