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目的:比较具有气道可逆性差异的慢性阻塞性肺疾病(COPD)患者呼出气冷凝液(EBC)中白三烯B4(LTB4)含量,了解对支气管舒张剂不同反应的COPD患者气道炎症的关系,探讨EBC分析对COPD表型研究的价值。方法:用酶免疫测定法测定EBC中LTB4的浓度,用统计学方法比较各组之间的差异性。结果:支气管舒张试验阴性COPD较哮喘低;差异有统计学意义(P<0.05);支气管舒张试验阳性的COPD较支气管舒张试验阴性的COPD者高;差异有统计学意义(P<0.05)。结论:对支气管舒张剂具有可逆性反应的COPD和哮喘气道炎症的机制可能有一定的重叠。EBC分析对COPD表型研究可能具有一定价值。
OBJECTIVE: To compare the levels of leukotriene B4 (LTB4) in exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) with different airway reversibility and to investigate the effects of bronchodilator on airway inflammation in COPD patients with different responses Relationship, explore the EBC analysis of COPD phenotype research value. Methods: The concentration of LTB4 in EBC was determined by enzyme immunoassay, and the differences between groups were compared by statistical methods. Results: The COPD of bronchial diastolic test was lower than that of asthma. The difference was statistically significant (P <0.05). The COPD of bronchodilator test was higher than that of COPD with bronchodilator test negative. The difference was statistically significant (P <0.05). CONCLUSIONS: There may be some overlap in the mechanisms of COPD and asthma airway inflammation that have reversible responses to bronchodilators. EBC analysis of COPD phenotype may have some value.