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我校附院中医科鉴于酸枣仁药源不足,刘秀荫等用枸杞子、何首乌和夜交藤各50克水煎剂(枸首藤合剂)代之治疗以失眠或伴心烦、心悸、形体消瘦,面色不华为主证之血虚失眠有明显疗效。我室用常规实验方法,按体表面积折算临床用量,对随机等分三组并饥饿8小时的30只小鼠灌胃给药(枸首藤各7.5克/公斤,枣仁2.25克/公斤,生理盐水对照)。半小时后以0.3%戊巴比妥钠溶液0.2毫升10克腹腔注射。结果两个给药组小鼠一般活动减少,对戊巴比妥钠睡眠时间的影响:枸首藤组与盐水组比较:P<0.001,枣仁组与盐水组比较P<0.001,枸首藤组与枣
In the Department of Traditional Chinese Medicine of the College of Affiliated School of our school, in view of the lack of source of Suanzaoren, Liu Xiugin used 50 grams of decoction of Radix medica, Radix Polygoni Multiflori and Radix Ranunculi, to treat it with insomnia or irritability, palpitations, emaciation, and complexion. There is no obvious effect of blood deficiency insomnia as the main syndrome. My laboratory used conventional experimental methods to convert the clinical dosage according to the body surface area and administered gavage to three groups of 30 mice that were randomly divided into three groups and starved for 8 hours (7.5 g/kg for Shantou vine, 2.25 g/kg for Zaolin, physiological Saline control). After half an hour, 0.2 ml 10 g of 0.3% pentobarbital sodium solution was intraperitoneally injected. RESULTS: The general activity of the mice in the two treatment groups was reduced, and the effect on the sleep time of pentobarbital sodium was compared between the Zhitoutou group and the saline group: P<0.001, and between the Zaozen group and the saline group, P<0.001. date