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血清SIgA主要是肠道相关的淋巴组织来源的多聚体IgA(PolymericIgA, P-IgA),用抗SIgA特有成分—分泌成分(Secretory Conponent, SC)抗血清可从血清总IgA中测出SIgA。由于SIgA存在肠肝循环,肝、胆疾病时含量可显著升高。本文报道丙型肝炎患者血清中SIgA含量。 对象和方法 一、对象: (一)正常人:35人。均为我院门诊体检合格的正常人,均无心、肝、肺、肾等重要脏器疾患、肝肾功能试验正常。 (二)病人组:31人。均为本院门诊和住院患者,全部病例均符合临床诊断,抗HCV阳性。 二、方法:放射免疫分析法。试剂盒IgA由上海放射免疫分析技术研究所提供,SIgA由中国同位素公司北方免疫试剂研究所提供,按各自说明书进行操作。受检者空腹抽血后,分离血清后冰冻保存
Serum SIgA is mainly composed of gut-associated lymphoid tissue-derived polymeric IgA (P-IgA), and SIgA is detected from total serum IgA using anti-SIgA-specific serum-secreting protein (SC). Due to the presence of SIgA enterohepatic circulation, liver and gallbladder disease levels may be significantly increased. This article reports the serum levels of SIgA in patients with hepatitis C. Objects and methods First, the object: (a) normal: 35 people. Are normal outpatient examination in our hospital were normal, are unintentional, liver, lung, kidney and other important organ diseases, liver and kidney function tests are normal. (B) the patient group: 31 people. All patients were outpatient and inpatient, all cases were in line with clinical diagnosis, anti-HCV positive. Second, methods: radioimmunoassay. The kit IgA is provided by Shanghai Institute of Radioimmunoassay, SIgA is supplied by China Isotope Corporation Northern ImmunoReagent Institute, and is operated according to the respective instructions. Subjects after fasting blood, isolated serum frozen