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目的 :探讨各种治疗眼眶特发性炎性假瘤 (IOIP)的疗效 ,特别是手术与激素治疗的疗效比较。方法 :对我院 1978年 1月到 1999年 12月住院的 2 0 9例IOIP作系统的回顾性研究 ,分析各种方法的疗效并比较手术与激素两种方法对IOIP的疗效差别。结果 :经手术、激素、局部放射、免疫抑制剂和COP方案化疗及上述方法联合治疗等 (随访 1个月到 2 1年 ,平均 1 5年 ) ,治愈率 40 2 % ( 84/ 2 0 9) ,部分治愈率 5 7 4% ( 12 0 / 2 0 9) ,复发率 43 % ( 3 4/ 80 )。手术治疗与激素治疗比较表明手术治疗和手术联合激素治疗的效果优于单纯激素治疗的效果 (P <0 0 0 1) ,但手术、激素及手术联合激素治疗三组间复发率无显著性差别 (P= 0 5 73 )。结论 :手术、激素和局部放射等治疗IOIP有效率和复发率均高 ,手术和手术联合激素治疗的效果优于单纯激素治疗 ,特别提出手术治疗在IOIP中的作用。如何提高完全治愈率和减少复发率是今后努力的方向
Objective: To investigate the efficacy of various treatments for idiopathic inflammatory pseudotumor of the orbit (IOIP), in particular the efficacy of surgery and hormone therapy. Methods: A retrospective study of 209 cases of IOIP hospitalized from January 1978 to December 1999 in our hospital was conducted. The curative effects of various methods were analyzed and the differences between the two methods of surgery and hormone on the efficacy of IOIP were compared. Results: The rate of cure was 40.2% (84/290) after surgery, hormones, local radiotherapy, immunosuppressive agents and COP regimen combined with the above methods (1 month to 21 years follow-up for an average of 15 years) ). The partial cure rate was 574% (12 0/209) and the recurrence rate was 43% (34/80). Surgical treatment and hormone therapy compared with surgery and surgery combined with hormone therapy is better than the effect of hormone therapy alone (P lt; 0 01), but surgery, hormones and surgery combined with hormone therapy, the three groups no significant difference in the recurrence rate (P = 0 5 73). CONCLUSIONS: Surgical, hormonal and local radiotherapy IOIP have high efficiency and recurrence rate. Surgical and surgical combined with hormone therapy are superior to those of simple hormone therapy. In particular, the role of surgical treatment in IOIP is proposed. How to improve the complete cure rate and reduce the recurrence rate is the direction of future efforts