【摘 要】
：
组氨酸三聚体核苷结合蛋白(HINT)属于HIT蛋白超家族,HINT1和HINT2基因分别位于人类染色体5q31.2和9p11区域,编码产物分别是含126和163个氨基酸的蛋白,相对分子质量分别约14 k
【机 构】
：
辽宁师范大学生命科学学院七鳃鳗研究中心,生物技术与分子药物研发省重点实验室,大连116081
论文部分内容阅读
组氨酸三聚体核苷结合蛋白(HINT)属于HIT蛋白超家族,HINT1和HINT2基因分别位于人类染色体5q31.2和9p11区域,编码产物分别是含126和163个氨基酸的蛋白,相对分子质量分别约14 kDa和17 kDa,二者之间有61％的序列同源性.HINT1在细胞中定位于细胞质和细胞核,HINT2定位于线粒体,二者在组织中分布广泛.HINT1和HINT2两个亚型均为肿瘤抑制因子,参与细胞增殖和凋亡,HINT1可通过调节Wnt/β-catenin信号通路以及p27KIP1、AP1、TFIIH、MITF等转录因子的活性抑制肿瘤,HINT2可通过线粒体自噬和线粒体凋亡途径抑制肿瘤.该文就HINT1和HINT2的发现、分布、结构、酶活性、肿瘤作用机制及其与其他疾病的关系进行了系统综述并进行展望.为进一步揭示HINT 1和HINT2在不同类型肿瘤中的分子抑制机制以及靶向治疗和药物研发奠定了理论基础.
其他文献
嗜肺军团菌可引起严重的非典型肺炎,其特殊的Dot/Icm IVB型分泌系统转运近330种效应蛋白(大多数作为蛋白酶发挥功能)至宿主细胞,通过修饰细胞调节因子、抑制细胞凋亡等一系列
The continuing COVID-19 pandemic and emergence of SARS-CoV-2 variants may cause this disease to transit into endemicity like seasonal flu.In a recent study,Bai
The mode of action of drugs used to treat depression has long remained mysterious.A new study now shows that unexpect-edly,this diverse group of chemicals binds
提高医学创新人才培养手段是医学教育改革的重点内容之一.“分子与细胞”是临床医学教育改革的重点专业基础课,也是一门全新的整合课程,具有学时多、难度大且要求和临床专业
银杏叶提取物(ginkgo biloba extract-761,EGb-761)注射液在中国常作为辅助药物被用于治疗脑卒中,但是,其潜在的细胞和药理机制尚未完全了解.该研究旨在探讨EGb-761是否通过
Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SID
The scaffolding protein gephyrin is a core component of many inhibitory synapses.Bai and colleagues now show that phase separation of gephyrin with the subunits
Exosome biogenesis occurs via multiple mechanisms,but how these pathways are controlled remains poorly understood.In a recent study published in Cell Research,W
The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vi
The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experi