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目的 调查睡眠呼吸暂停综合征 (SAS)患者接受经鼻持续气道正压通气 (nCPAP)治疗的依从性、主观疗效和不良反应 ,了解影响依从性的相关因素。方法 对我院 1994年 2月～ 2 0 0 0年 8月间接受nCPAP治疗的 118例SAS患者进行有关依从性的问卷调查并分析其影响因素。结果 118例SAS患者中 5 7%应用nCPAP依从性良好 ,影响nCPAP治疗依从性的因素主要有治疗前睡眠呼吸暂停 /低通气指数 (AHI) (P =0 0 35 )、治疗前夜间最低血氧饱和度 (LSaO2 ) (P =0 0 0 6 )、治疗前及后Epworth嗜睡评分 (ESS) (P值均 <0 0 0 1)及CPAP呼吸机的性能 (P <0 0 0 1)。结论 5 7%的SAS患者能长期坚持应用nCPAP治疗 ,nCPAP可作为SAS长期治疗的重要手段 ;影响nCPAP治疗依从性的因素主要有治疗前AHI、治疗前夜间LSaO2 、治疗前及后ESS及CPAP呼吸机的性能。
Objective To investigate the compliance, subjective efficacy and side effects of nasal continuous positive airway pressure (nCPAP) therapy in patients with sleep apnea syndrome (SAS) and to understand the related factors that influence compliance. Methods A total of 118 SAS patients undergoing nCPAP between February 1994 and August 2000 were surveyed and their influencing factors were analyzed. Results Fifty-seven percent of 118 patients with SAS had good compliance with nCPAP. The factors influencing the compliance of nCPAP therapy included pre-treatment sleep apnea / hypopnea index (AHI) (P = 0 35), pre-treatment night minimum oxygen saturation (P = 0.0060), Epworth sleepiness score (ESS) before and after treatment (P <0 0 01) and CPAP ventilator performance (P 0 001). CONCLUSIONS: Fifty-seven percent of patients with SAS consistently adhere to nCPAP for long-term treatment. NCPAP may be an important treatment for long-term treatment of SAS. The factors that influence nCPAP compliance include AHI before treatment, LSaO2 before treatment, ESS and CPAP before and after treatment Machine performance.