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血清肌酐(Cr)浓度能准确地反映肾小球滤过率(GFR),因内源性产生Cr的速率几乎恒定,而且几乎毫无例外地通过肾小球滤过而排出。用血尿素氮(BUN)浓度反映GFR则准确性较差,因尿素产生速率和肾小管的重吸收均波动很大。在肾功能恶化时,血中尿素和Cr浓度同时升高,其尿素与Cr比例一般约为10:1。当BUN浓度与血清Cr浓度不成比例升高时,一般认为血清Cr反映GFR,而BUN过度升高是由肾外因素引起,如尿素产生增加或肾小管重吸收增加。在某些患者。尤其伴有低GFR者,肾小
Serum creatinine (Cr) concentrations accurately reflect glomerular filtration rate (GFR) as the rate of endogenous Cr production is almost constant and is almost exclusively eliminated by glomerular filtration. Reflecting GFR using blood urea nitrogen (BUN) concentrations is less accurate because of the wide fluctuations in urea production and renal tubular reabsorption. In the deterioration of renal function, blood urea and Cr concentrations increased at the same time, the ratio of urea and Cr is generally about 10: 1. When the BUN concentration increases disproportionately with serum Cr concentration, serum Cr is thought to reflect GFR, whereas excessive BUN is caused by extrarenal factors such as increased urea production or tubular reabsorption. In some patients. Especially with low GFR, kidney