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目的:探讨溶血磷脂酸在健康体检中的应用价值。方法:选取50岁以上有高血压、糖尿病、高脂血症其中之一项或多项的体检者200名,检测其血压、血糖、血脂、血浆LPA含量。随访观察6个月,每月测定血浆LPA、血糖、血脂各一次,高血压、糖尿病、高脂血症患者记录其控制血压、血糖、血脂的服药情况及治疗效果。以血浆LPA含量2.20μmol·L-1为正常值的上限,分为LPA升高组与LPA正常组两组,以发生缺血性脑血管病为主要终点事件,以发生急性冠脉综合征或其它急性血栓性疾病为次要终点事件。以是否发生终点事件分组,比较两组间血浆LPA含量及血压、血糖、血脂的控制情况。结果:LPA升高组发生主、次要终点事件均高于LPA正常组,差异有统计学意义(P<0.01),其LPA值、收缩压、舒张压、空腹血糖、TC、TG、LDL均高于LPA正常组,HDL低于LPA正常组,差异有统计学意义(P<0.01)。终点事件发生组事件发生前LPA值明显高于无终点事件发生组,其收缩压、舒张压、空腹血糖、TC、TG、LDL均显著高于无终点事件发生组,HDL低于无终点事件发生组,差异有统计学意义(P<0.01)。结论:血压、血糖、血脂等卒中危险因素控制不良时,血浆LPA含量升高。血浆LPA含量越高提示发生缺血性脑血管病及其他急性血栓性疾病的风险越大。健康体检时检测血浆LPA含量有助于积极防治缺血性脑血管疾病。
Objective: To investigate the value of lysophosphatidic acid in healthy physical examination. Methods: A total of 200 subjects over 50 years old with hypertension, diabetes and hyperlipidemia were selected and their blood pressure, blood glucose, blood lipids and plasma LPA levels were measured. Follow-up observation of 6 months, monthly measurement of plasma LPA, blood glucose, lipid each time, hypertension, diabetes, hyperlipidemia patients recorded its control of blood pressure, blood glucose, blood lipid medication and treatment. To plasma LPA content of 2.20μmol·L-1 for the upper limit of normal, divided into LPA increased group and LPA normal group two groups, the occurrence of ischemic cerebrovascular disease as the main endpoint of the event of acute coronary syndrome or Other acute thrombotic diseases are secondary endpoints. To determine whether end-point events occurred or not, the level of plasma LPA and the control of blood pressure, blood glucose and blood lipids were compared between the two groups. Results: The incidence of primary and secondary end points in LPA increased group was higher than that in LPA normal group (P <0.01), LPA value, systolic blood pressure, diastolic blood pressure, fasting blood glucose, TC, TG and LDL Higher than LPA normal group, HDL lower than LPA normal group, the difference was statistically significant (P <0.01). The LPA value of the event group before end point event was significantly higher than that of the end point event group, and systolic blood pressure, diastolic blood pressure, fasting blood glucose, TC, TG, LDL were significantly higher than those without end point event, and HDL was lower than that without end point event Group, the difference was statistically significant (P <0.01). Conclusion: Plasma LPA levels are elevated in poorly controlled stroke risk factors such as blood pressure, blood glucose, and lipids. The higher plasma LPA levels indicate a greater risk of developing ischemic cerebrovascular disease and other acute thrombotic diseases. The detection of plasma LPA during physical examination helps to prevent and treat ischemic cerebrovascular diseases.