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采用免疫组织化学和组织病理学方法对食管癌高发区河南省林州市（原林县）居民、当地居民家庭饲养的猪以及甲基苄基亚硝胺诱发的ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠食管上皮病变和肿瘤抑制基因Ｐ５３的改变进行比较研究。结果：大鼠和猪食管上皮增生性改变，特别是基底细胞增生和间变的形态学改变与人食管上皮改变非常相似；大鼠食管上皮癌变各阶段未见明显Ｐ５３蛋白的改变，猪食管上皮特别是间变组织出现与人相似的Ｐ５３免疫阳性反应。提示：食管癌高发区居民饲养的猪可能是一种有价值的研究食管癌变机理的自然动物模型。
Immunohistochemical and histopathological methods for esophageal epithelial lesions in Sprague-Dawley rats induced by residents of Linzhou City (formerly Linxian) in Henan Province, pigs raised by local households, and methylbenzylnitrosamines in high-incidence areas of esophageal cancer A comparative study of changes in tumor suppressor gene P53 was performed. RESULTS: The hyperplasia of the esophageal epithelium in rats and pigs, especially the morphological changes of basal cell hyperplasia and interstitial changes were very similar to those in human esophageal epithelium; there was no obvious change in P53 protein in the esophageal epithelial carcinogenesis in rats, and pig esophageal epithelium In particular, P53 immunopositive reactions similar to humans occur in metaplastic tissue. Tip: Pigs raised by residents of high-incidence areas of esophageal cancer may be a valuable natural animal model to study the mechanism of esophageal canceration.