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目的制备盐酸胺碘酮固体分散体,测定其体外溶出度,同时与普通胶囊剂的体外溶出度比较。方法以聚乙二醇6000(PEG6000)为载体,溶剂熔融法制备盐酸胺碘酮固体分散体,用紫外分光光度法测定体外溶出度。结果盐酸胺碘酮固体分散体的体外溶出度比普通胶囊剂显著提高。结论成功制备了盐酸胺碘酮固体分散体。
OBJECTIVE To prepare solid dispersions of amiodarone hydrochloride for determination of in vitro dissolution and to compare with in vitro dissolution of common capsules. Methods The solid dispersion of amiodarone hydrochloride was prepared by PEG6000 with solvent melting method. The dissolution rate in vitro was determined by UV spectrophotometry. Results Amiodarone hydrochloride solid dispersions in vitro dissolution significantly higher than the ordinary capsules. Conclusion Amiodarone hydrochloride solid dispersions were successfully prepared.