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绒毛膜促性腺激素(hCG或HCG)由绒毛滋养叶细胞产生,经孕妇尿中排出,测定其含量可间接推断此类细胞的功能状态,对正常和异常妊娠以及滋养叶细胞疾患的诊断、治疗、随诊都有重要意义。以往测定hCG仅以定性试验作粗略估计,近年来,随着免疫学和放射免疫学的进展,可以做半定量及定量测定,为临床医师提供了更为精确的客观数据。本文除扼要介绍几种临床常用测定方法的敏感度和hCG单位换算方法外,主要综合在正常妊娠、先兆流产、死胎、宫外孕、葡萄胎、恶性葡萄胎及绒癌时hCG的数据及其诊断指标,借以参考。一、几种常用hCG测定方法的敏感度及单位换算(一)生物学试验用兔、鼠、青蛙、蟾蜍等。目前
Chorionic gonadotropin (hCG or HCG) is produced by villous trophoblast cells and excreted in the urine of pregnant women. The determination of its content can indirectly infer the functional status of such cells. The diagnosis and treatment of normal and abnormal pregnancy and trophoblastic diseases , Follow-up has important significance. In the past, hCG was only estimated roughly by qualitative test. In recent years, with the progress of immunology and radioimmunology, semi-quantitative and quantitative determination of hCG can be done, which provides clinicians with more accurate objective data. In addition to briefly introduce the sensitivity of several clinical commonly used assay methods and hCG unit conversion method, the data of hCG in normal pregnancy, threatened abortion, stillbirth, ectopic pregnancy, hydatidiform mole, malignant mole and choriocarcinoma and their diagnostic criteria , For reference. First, the sensitivity of several commonly used methods of hCG determination and unit conversion (a) Biological experiments with rabbits, rats, frogs, toads and so on. Currently