[目的]探讨腹腔镜胆囊切除应用内镜下逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)取石围术期护理干预效果。[方法]将80例腹腔镜胆囊切除应用ERCP取石病人按随机数字表法分为对照组和观察组各40例,对照组病人给予常规护理,观察组病人则给予围术期护理干预,比较两组的护理效果和护理满意度,观察两组病人术后并发症发生情况。[结果]观察组病人的手术时间、排气时间、下床活动时间、住院时间和住院费用均明显低于对照组,两组间差异有统计学意义(P<0.05);观察组病人并发症发生率为5.00%,明显低于对照组的22.50%,两组间差异有统计学意义(P<0.05);观察组护理满意度为95.00%,明显高于对照组的80.00%,两组间差异有统计学意义(P<0.05)。[结论]腹腔镜胆囊切除应用ERCP取石病人实施围术期护理可有效降低并发症发生率,提高护理满意度。 [Objective] To investigate the effect of nursing intervention in endoscopic retrograde cholangiopancreatography (ERCP) during laparoscopic cholecystectomy. [Method] Eighty patients undergoing laparoscopic cholecystectomy with ERCP were randomly divided into control group and observation group according to random number table method, 40 patients in control group were given routine nursing, and patients in observation group were given perioperative nursing intervention. Group nursing effect and nursing satisfaction, observe the incidence of postoperative complications in two groups of patients. [Results] The operation time, exhaust time, ambulation time, hospitalization time and hospitalization cost in the observation group were significantly lower than those in the control group, with significant difference between the two groups (P <0.05). The observation group patients’ complication (P0.05) .The nursing satisfaction of the observation group was 95.00%, which was significantly higher than that of the control group (80.00%). The difference between the two groups was statistically significant (P0.05) The difference was statistically significant (P <0.05). [Conclusion] Laparoscopic cholecystectomy with ERCP in patients undergoing perioperative nursing can effectively reduce the incidence of complications and improve nursing satisfaction.