美国食品和药品管理局(FDA)于2011年12月15日发布公告,放宽降脂药辛伐他汀与抗心律失常药物胺碘酮联用时的限制剂量,从10 mg/d增至20 mg/d,同时对辛伐他汀药品说明书相应内容做出更新[1-2]。辛伐他汀药品说明书的内容曾于2002年进行更新,警告与胺碘酮合用时辛伐他汀剂量>20 mg/d将增加导致横纹肌溶 The U.S. Food and Drug Administration (FDA) issued a public notice on December 15, 2011 to ease the reduction of the dose of simvastatin in combination with the antiarrhythmic drug amiodarone from 10 mg / d to 20 mg / d, at the same time on the simvastatin drug instructions to update the corresponding content [1-2]. Simvastatin drug specification was updated in 2002, warning amiodarone combined with simvastatin dose> 20 mg / d will lead to rhabdomyolysis