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在麻醉的SD雄性大鼠上,观察到粉防己碱(Tetrandrine,Tet)30mg/kg 2/d,ig连续4d能显著地降低血压,而对心率和血浆肾素活性(PRA)无明显影响。一次静注Tet 15 mg/kg,血压降低的同时伴有心率减慢,也不影响PRA。先用Tet连续灌胃4d后的动物,一次静注Tet引起同等程度的降压效应,说明Tet的降压作用无耐受现象。在离体实验中发现,Tet抑制电刺激引起的心室乳头肌收缩及门静脉纵条的自主收缩,EC_(50)分别为5.33×10~(-6)mol/L和4.25×10~(-5)mol/L,Tet的血管选择性为0.12。
In anesthetized SD male rats, tetrandrine (Tet) at 30 mg / kg 2 / d was observed for ig for 4 consecutive days with significant reductions in blood pressure with no significant effect on heart rate and plasma renin activity (PRA). A single intravenous infusion of Tet 15 mg / kg, accompanied by a decrease in heart rate and a decrease in blood pressure, does not affect PRA. First Tet continuous gavage after 4d animals, a single intravenous Tet cause the same degree of antihypertensive effect, indicating that the antihypertensive effect of Tet no tolerance. In vitro experiments showed that Tet inhibited the contraction of papillary muscles and the spontaneous contraction of portal vein strips induced by electrical stimulation. The EC50 values were 5.33 × 10 ~ (-6) mol / L and 4.25 × 10 ~ (-5) ) mol / L, the blood vessel selectivity of Tet is 0.12.