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Neuronal-glial circuits underlie integrative processes in the nervous system.Func-tion of glial syncytium is,to a very large extent,regulated by the intracellularcalcium signaling system.Glial calcium signals are triggered by activation ofmultiple receptors,expressed in glial membrane,which regulate both Ca~(2+) entryand Ca~(2+) release from the endoplasmic reticulum.The endoplasmic reticulum alsoendows glial cells with intracellular excitable media,which is able to produce andmaintain long-ranging signaling in a form of propagating Ca~(2+) waves.In patho-logical conditions,calcium signals regulate glial response to injury,which mighthave both protective and detrimental effects on the nervous tissue.
Neuronal-glial circuits underlie integrative processes in the nervous system. Func-tion of glial syncytium is, to a very large extent, regulated by the intracellularcalcium signaling system. Glial calcium signals are triggered by activation of multiple receptors, expressed in glial membrane, which regulate both Ca 2+ entryand Ca 2+ release from the endoplasmic reticulum also endogenous glial cells with intracellular excitable media, which is able to produce andmaintain long-ranging signaling in a form of propagating Ca 2+ +) waves.In patho-logical conditions, calcium signals regulate glial response to injury, which mighthave both protective and detrimental effects on the nervous tissue.