体内产生的活性氧(ROS)既是导致正常细胞癌变,是恶性肿瘤发生的主要原因之一,同时又是大多数化疗药物和放射治疗恶性肿瘤的主要机制之一,这种双向作用正是通过不同的信号通路和机制来实现的。利用外源性物质产生ROS及治疗肿瘤,是新药设计和研发的科学理论基础。本文对参与ROS致癌/抗癌的不同作用机制进行概述,为预防、控制和治疗恶性肿瘤提供新思路。 Reactive oxygen species (ROS) produced in vivo is not only the cause of canceration of normal cells, but also one of the main mechanisms of malignant tumor. It is also one of the main mechanisms of most chemotherapeutic drugs and radiation therapy of malignant tumors. It is through different Signal path and mechanism to achieve. The use of exogenous substances to produce ROS and the treatment of cancer is the scientific basis for the design and development of new drugs. This article summarizes the different mechanisms of action involved in the carcinogenesis / anticancer of ROS and provides new ideas for the prevention, control and treatment of malignant tumors.