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【目的】观察顺铂不同腹腔注射方式联合瘤内注射32P玻璃微球(32P-GMS)对裸鼠舌鳞癌移植瘤的生长抑制效果,探讨顺铂不同腹腔注射方式对32P-GMS间质注射内放射的增敏效果。【方法】将40只荷瘤人舌鳞癌Tca8113细胞裸鼠随机分为4组,每组10只(空白对照组、单纯32P-GMS组、大剂量顺铂联合32P-GMS组和小剂量顺铂联合32P-GMS组),分别处理两周后取出肿瘤称瘤体质量,计算各组抑瘤率,比较各治疗组对移植瘤生长的抑制作用。【结果】单纯32P-GMS组、小剂量顺铂联合32P-GMS组及大剂量顺铂联合32P-GMS组抑瘤率分别为46%、78%、57%。【结论】多次小剂量顺铂较单次大剂量顺铂对32P玻璃微球对裸鼠舌鳞癌移植瘤的生长抑制作用有更明显增强效果。
【Objective】 To observe the inhibitory effect of cisplatin combined with intraperitoneal injection of 32P-GMS on the growth of human tongue squamous carcinoma in nude mice and the effect of cisplatin injection on 32P-GMS interstitial injection Radiation sensitization effect. 【Methods】 Forty Tca8113 tumor-bearing human tongue squamous cell carcinoma-bearing nude mice were randomly divided into 4 groups with 10 rats in each group (blank control group, pure 32P-GMS group, high-dose cisplatin combined with 32P-GMS group and low dose cis Platinum combined with 32P-GMS group). The tumors were removed after two weeks and the tumor weight was calculated. The inhibition rate of each group was calculated, and the inhibitory effect on the growth of xenografts was compared between the two groups. 【Results】 The inhibitory rates of 32P-GMS group, low-dose cisplatin combined with 32P-GMS group and high-dose cisplatin combined with 32P-GMS group were 46%, 78% and 57%, respectively. 【Conclusions】 Multiple small doses of cisplatin have a more significant effect on the growth inhibition of xenografted tongue squamous carcinoma in nude mice than single high-dose cisplatin.