微卫星标记是以1-6个碱基为重复单位组成的简单串联重复序列,其广泛存在于各类真核生物基因组中,一般为散在分布的中等程度重复序列,具有数量多、多态性高、共显性遗传、选择中性和可重复性好等优点,近年来常用于研究生物的遗传多态性。本文简述了微卫星标记技术基本原理、优点和检测方法及其在疟原虫遗传多态性研究中的应用。 Microsatellite markers are simple tandem repeats consisting of 1-6 bases as repetitive units. They are widely found in various eukaryotic genomes and are generally scattered, moderately repetitive sequences with a large number of polymorphic High, co-dominant inheritance, the choice of neutrality and good reproducibility, etc., in recent years often used to study genetic polymorphism. This article briefly describes the basic principles, advantages and detection methods of microsatellite markers and their applications in the study of genetic polymorphisms of Plasmodium.