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目的 :探讨止痛胶囊对于大鼠的镇痛作用及其机理。方法 :采用光热刺激鼠尾—逃避法 (Tailflicktest)测定大鼠痛阈。结果 :止痛胶囊能剂量依赖性地提高大鼠光热刺激鼠尾—逃避法的痛阈 ;纳洛酮能部分翻转止痛胶囊的镇痛作用。结论 :止痛胶囊具有镇痛作用 ,其镇痛作用可能涉及阿片受体
Objective: To investigate the analgesic effect of Zhitong capsule on rats and its mechanism. METHODS: The pain threshold of rats was measured by photothermal stimulation of tail-escape method (Tailflicktest). Results: The Zhitong capsule could increase the photosensitivity of rat tail-escaping method in a dose-dependent manner, and the analgesic effect of naloxone partially flipped Zhitong capsule. Conclusion: Analgesic capsules have analgesic effect and its analgesic effect may involve opioid receptors