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目的：探讨阻断颈部淋巴引流大鼠血压、心率、整体调节功能的变化。方法：将Ｗｉｓｔａｒ大鼠分成两组：对照组（ｎ＝１０）接受假手术；淋巴引流阻断组（ｎ＝１０）结扎颈浅及颈深淋巴管并摘除淋巴结以造成淋巴性脑水肿。两组均在术后第７天进行正立位倾斜应激试验及倒立位倾斜应激试验，其间连续测定动脉血压、心率、Ⅱ导ＥＣＧ、顶部ＥＥＧ及其能量曲线等，并观察整体压力感受器反射灵敏度（ＢＳ）。结果：对照组大鼠正立位初动脉血压降低，尔后迅速恢复正常；倒立位初动脉血压升高，但随后迅速回降。当阻断两侧颈总动脉血流时，动脉血压升高，ＥＥＧ不变。淋巴引流阻断组大鼠正立位及倒立位时动脉血压均持续显著低于正常水平，出现心律紊乱，ＢＳ降低。阻断两侧颈总动脉后动脉血压反而降低，脑电图变平坦，脑电能量曲线几乎减小至零。结论：大鼠颈淋巴引流障碍，可导致血压、心率、ＥＥＧ调节功能减弱，压力感受器灵敏度降低，易产生体位性低血压。
OBJECTIVE: To investigate the changes of blood pressure, heart rate and global regulatory function in blocking lymphatic drainage of the neck. Methods: The Wistar rats were divided into two groups: the control group (n = 10) undergoing sham operation; the lymphatic drainage block group (n = 10) ligating the superficial and deep cervical lymphatic vessels and removing the lymph nodes to cause lymphatic edema. Both groups were on the 7th day postoperative orthostatic tilt stress test and inverted position tilt stress test, continuous measurement of arterial blood pressure, heart rate, Ⅱ ECG, the top of the EEG and its energy curve, and the overall baroreceptor Reflection sensitivity (BS). Results: In the control group, the orthostatic blood pressure decreased immediately and returned to normal immediately. The blood pressure of the contralateral initial artery was increased, but then rapidly dropped back. When blocking both common carotid arteries, arterial blood pressure increased, EEG unchanged. In the lymphatic drainage block group, the arterial blood pressure in the upright position and in the upright position continued to be significantly lower than the normal level, and the heart rhythm disorder and BS were decreased. After blocking the common carotid artery on both sides but lower arterial blood pressure, EEG flatten, EEG energy curve is almost reduced to zero. CONCLUSION: Disorders of cervical lymphatic drainage in rats can lead to the decrease of blood pressure, heart rate, EEG regulating function, decrease of sensitivity of baroreceptor and easy to produce orthostatic hypotension.