论文部分内容阅读
目的:探讨滋肾柔肝汤对抗精神病药物所致高催乳素血症男性患者性激素以及体重的影响。方法:高催乳素血症患者中51例服用滋肾柔肝汤为研究组,59例服用安慰剂为对照组,治疗疗程共12周,在基线、4周、8周和12周时,对两组患者血清催乳素、黄体生成激素、卵泡生成激素、雌二醇、孕酮、睾酮以及阳性与阴性症状量表(PANSS)等进行评定。结果:滋肾柔肝汤组在治疗12周后与基线比较催乳素较前降低(t=-3.602,P<0.01),体质指数较前降低(t=-6.259,P<0.01),而雌二醇较前升高(t=5.520,P<0.01),卵泡生成激素较前升高(t=3.090,P<0.01),睾酮较前升高(t=10.004,P<0.01)。对照组在治疗12周后,各性激素水平以及体质指数与基线时比较无明显统计学差异(P>0.05)。治疗前后两组患者PANSS评分没有统计学差异(P>0.05)。结论:滋肾柔肝汤可以降低抗精神病药物所致高催乳素血症患者的催乳素水平,提高体内睾酮、雌激素和卵泡生成激素水平,可以减轻患者体质指数,对精神分裂症患者精神症状无明显影响。
Objective: To investigate the effect of Zishen Rougan Decoction on sex hormones and body weight in men with hyperprolactinemia induced by psychotropic drugs. Methods: 51 cases of hyperprolactinemia patients taking Zishen Rougan Tang as study group, 59 patients taking placebo as control group, the treatment course of 12 weeks, at baseline, 4 weeks, 8 weeks and 12 weeks, Serum prolactin, luteinizing hormone, follicle-stimulating hormone, estradiol, progesterone, testosterone and positive and negative symptom scales (PANSS) were evaluated in both groups. Results: Compared with the baseline, prolactin in Zishen Rougan Decoction group was lower than before (t = -3.602, P <0.01) and body mass index was lower than before (t = -6.259, P <0.01) (T = 5.520, P <0.01), follicle-stimulating hormone (t = 3.090, P <0.01) and testosterone (t = 10.004, P <0.01). The control group after 12 weeks of treatment, the sex hormone levels and body mass index compared with baseline no significant difference (P> 0.05). There was no significant difference in PANSS scores between the two groups before and after treatment (P> 0.05). Conclusion: Zishen Rougan Decoction can reduce the level of prolactin in patients with hyperprolactinemia induced by antipsychotics and increase the levels of testosterone, estrogen and follicle-forming hormone in the body, which can reduce the body mass index of patients and alleviate the symptoms of schizophrenia No significant effect.