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目的探讨维药固精麦斯哈片对正常雄性大鼠性行为学的影响。方法正常性成熟雄性SD大鼠20只,随机分为正常对照组和固精麦斯哈片组,每组10只。固精麦斯哈片组360mg/kg,每日2次给予固精麦斯哈片灌胃,正常对照组给予10ml/kg生理盐水灌胃,连续6w。于固精麦斯哈片干预第2w末、第4w末、第6w末分别进行大鼠性行为学及APO试验检测。结果性行为学试验结果表明:固精麦斯哈片干预2w,与正常对照组相比,固精麦斯哈片组骑跨潜伏期延长、插入潜伏期、射精潜伏期有所延长,但是差异无统计学意义(P>0.05);固精麦斯哈片干预延长至4w到6w,骑跨潜伏期延长、插入潜伏期、射精潜伏期明显延长,差异有统计学意义(P<0.01);固精麦斯哈片干预2w至6w,固精麦斯哈片组骑跨次数、插入次数、射精次数均减少,差异无统计学意义(P>0.05)。APO试验的测定结果显示,固精麦斯哈片干预2w,固精麦斯哈片组较正常对照组APO勃起潜伏期显著延长,差异无统计学意义(P>0.05),固精麦斯哈片干预延长至4w到6w,APO勃起潜伏期显著延长,差异有统计学意义(P<0.01);固精麦斯哈片干预2w至6w,固精麦斯哈片组APO勃起次数降低,差异无统计学意义(P>0.05)。结论维药固精麦斯哈片对正常雄性大鼠性行为和射精功能具有调节作用。
Objective To investigate the effect of Weiyu Gujing Haoshu tablet on the sexual behavior of normal male rats. Methods Twenty normal male SD rats were randomly divided into normal control group and Decoction group, 10 rats in each group. Solid Jing Maxi Ha film group 360mg / kg, 2 times a day to give solid fine Masashi tablets gavage, normal control group given 10ml / kg saline for 6 weeks. At the end of 2w, 4w and 6w, the rats were subjected to sex and APO test respectively. Results of behavioral test showed that Gudong Jingmaijia Tablets intervened for 2 weeks, compared with normal control group, Gou Jing Masu Ha Tablets extended lassage latency, insertion latency, ejaculation latency was prolonged, but the difference was not statistically significant ( P> 0.05). The intervention of Gushen Haisu Tablet prolonged from 4w to 6w, and the latent period of insertion was prolonged. The latency of ejaculation was significantly prolonged (P <0.01) , And the number of rides, insertion times and ejaculation times in GMS group were all decreased with no significant difference (P> 0.05). The results of APO test showed that the APO edema incubation period was significantly longer than that of the control group (P> 0.05), and the intervention of GMCS was prolonged to 4w to 6w, APO erection latency was significantly longer, the difference was statistically significant (P <0.01); Gu Jing Ha Se intervention for 2w to 6w, APO ejaculation group APO erection frequency decreased, the difference was not statistically significant (P> 0.05). Conclusion Weiyu Gu Jing Jing Ma Ha Ha tablets on normal male rats sexual behavior and ejaculation function has a regulatory role.