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目的分析本院摩根摩根菌的临床分布和耐药性,为临床合理选用抗菌药物提供依据。方法采用WHONET5.6软件对2014年6月-2016年6月分离到摩根摩根菌的标本来源以及药敏试验结果进行回顾性分析。结果共分离到摩根摩根菌420株,主要来源于尿液,占38.0%;其次是痰液,占28.3%;摩根摩根菌对青霉素类和第一代头孢霉素等常见抗生素耐药严重,如对氨苄西林、阿莫西林、头孢唑林等耐药率均>99%;对第三代头孢菌素类抗菌药物(头孢噻肟、头孢他啶、头孢曲松)的耐药率分别为50.0%、33.8%和16.2%;对碳青霉烯类抗菌药敏感,如对亚胺培南、美洛培南等耐药率<2%。结论摩根摩根菌可在多种标本中被检到,耐药情况比较严重;亚胺培南、厄他培南等可以作为临床治疗该菌的一线药物,提高治疗效果。
Objective To analyze the clinical distribution and drug resistance of Morganella morganii in our hospital and provide basis for the rational use of antibacterials in clinic. Methods WHONET5.6 software was used to analyze the source of specimens of M. morganii isolated from June 2014 to June 2016 and the results of drug susceptibility test. Results A total of 420 strains of Morganella were isolated, mainly from urine, accounting for 38.0%; followed by sputum, accounting for 28.3%; Morganella morgani was resistant to common antibiotics such as penicillins and first-generation cephalosporins, The resistance rates to ampicillin, amoxicillin and cefazolin were both above 99%. The rates of resistance to the third generation cephalosporin antibiotics (cefotaxime, ceftazidime and ceftriaxone) were 50.0% 33.8% and 16.2%, respectively. They were sensitive to carbapenem antibiotics, such as resistance rate to imipenem and meropenem <2%. Conclusion Morganella morgani can be detected in a variety of specimens and the drug resistance is rather serious. Imipenem and ertapenem can be used as first-line drugs in the clinical treatment of the bacterium to improve the therapeutic effect.