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关于急性肺损伤(ALI)的生物标志物种类较多,但目前尚未发现具有特异性的一种。肺表面活性蛋白D(SP-D)主要是由肺泡Ⅱ型上皮细胞分泌,在机体肺部防御和免疫调节方面发挥重要作用,与多种肺部疾病相关,是ALI/急性呼吸窘迫综合征(ARDS)发生、发展的重要参与者,可以作为ALI的生物标志物。现就SP-D的生化结构、功能及其在ARDS中的浓度变化等进行综述。
There are many types of biomarkers for acute lung injury (ALI), but no specific one has been found so far. Pulmonary surfactant protein D (SP-D), secreted mainly by type II alveolar epithelial cells, plays an important role in the defense and immune regulation of the lungs of the body and is associated with a variety of pulmonary diseases and is a hallmark of ALI / Acute Respiratory Distress Syndrome ARDS) occurred, an important player in the development, can be used as a biomarker of ALI. The biochemical structure and function of SP-D and its concentration change in ARDS are reviewed.