目的:比较喘平方在大鼠与人体内药代动力参数。方法:采用HPLC测定SD大鼠血液与人尿中麻黄碱和伪麻黄碱质量浓度,通过3P87软件计算大鼠血液中药动学参数,尿药亏量法计算人尿中药动学参数。结果:喘平方在大鼠体内与人体内药代动力学参数不尽相同。复方中麻黄与洋金花相互作用对麻黄碱、伪麻黄碱在大鼠体内的代谢无明显影响,但对2种成分在人体内代谢有影响,结论:药物高剂量给药在动物体内代谢过程与正常服用剂量在人体内代谢过程存在差异,动物高剂量给药试验不能如实反映药物在人体内代谢过程。 OBJECTIVE: To compare the pharmacokinetic parameters of asthma in rats and humans. Methods: The concentrations of ephedrine and pseudoephedrine in the blood and human urine of SD rats were determined by HPLC. The pharmacokinetic parameters of blood were calculated by 3P87 software. The pharmacokinetic parameters of human urine were calculated by the method of urine loss. Results: There are different pharmacokinetic parameters of ChuanPingFang in rats and in vivo. The interaction between ephedrine and oriental inflorescence in compound has no significant effect on the metabolism of ephedrine and pseudoephedrine in rats, but has an effect on the metabolism of the two components in human body. Conclusion: The high-dose administration of the drug in the animal is similar to the normal Taking the dose in the human body metabolic process differences, high doses of animal drug testing can not accurately reflect the drug metabolism in the human body.