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目的:研究辛伐他汀作为激活物对骨生成的促进作用。方法:通过制备大鼠胫骨骨缺损模型填入Bio-oss骨粉,同时给予口服辛伐他汀(实验组),并设立空白组、对照组(骨缺损单纯填入Bio-oss骨粉),于术后4、8、12周分别处死大鼠,进行定性、定量分析,观测骨增量变化。结果:空白组无法形成正常骨愈合;实验组在骨量形成和新骨改建速度方面明显优于对照组。结论:辛伐他汀有促进新骨生成作用。
OBJECTIVE: To study the effects of simvastatin as an activator on osteogenesis. Methods: Bio-oss bone meal was infused into the osteosarcoma of the tibia in rats, and Simvastatin orally (experimental group) was given. The blank group and the control group (bone defect simply filled with Bio-oss bone meal) The rats were sacrificed at 4, 8 and 12 weeks respectively for qualitative and quantitative analysis, and the changes of bone increments were observed. Results: The blank group could not form normal bone healing. The experimental group was significantly better than the control group in terms of bone mass formation and new bone remodeling rate. Conclusion: Simvastatin can promote new bone formation.