类风湿性关节炎是一种慢性、系统性、自身免疫性疾病,以关节滑膜、软骨、部分骨质和关节周围组织侵蚀的慢性炎症为特征。晚期可导致严重的关节畸形、疼痛,特别是人体大关节的受累,严重影响患者的生活质量~[1]。全膝关节置换术(TKA)可减轻患者疼痛,重新建立人工关节接触面,矫正下肢负重力线、畸形,疗效肯定,明显改善了晚期类风湿性关节炎患者的生活质量~[2-4]。血沉(ESR)和C反应蛋白(CRP)是炎性反应和组织损伤程度的非特异性标志物,根据ESR和CRP水平变化可以 Rheumatoid arthritis is a chronic, systemic, autoimmune disease characterized by chronic inflammation of the synovium, cartilage, part of the bone, and erosion of the tissues around the joint. Late can lead to serious joint deformities, pain, especially the human body joints affected, seriously affecting the quality of life of patients ~ [1]. Total knee arthroplasty (TKA) can reduce the patient’s pain, re-establish the artificial joint contact surface, correct the negative force line, deformity, curative effect, significantly improve the quality of life in patients with advanced rheumatoid arthritis ~ [2-4] . Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are nonspecific markers of inflammatory response and tissue damage that vary according to ESR and CRP levels