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目的观察生活方式干预联合阿卡波糖治疗糖耐量异常(IGT)合并代谢综合征(MS)的效果。方法将2010年10月-2011年9月IGT合并MS患者210例随机分为对照组和治疗组,两组均给予生活方式干预,包括低盐低脂低热量饮食、适当运动、控制体重,戒烟饮酒及心理指导等,治疗组联用阿卡波糖50 mg,3次/d,对照组加用维生素C 100 mg,3次/d。观察12周后两组治疗前后体质量指数(BMI)、甘油三酯(TG)、空腹血糖(FPG)及餐后2 h血糖(2 hPG)的变化。结果治疗后两组BMI、TG、FPG、2 hPG均明显下降(对照组t=7.118,2.708,10.012,8.797;治疗组t=8.948,4.053,10.662,9.852;P均<0.05或0.01)。与对照组比较,治疗组在治疗后BMI、TG、FPG、2 hPG等指标明显降低(t=2.894,2.209,9.675,3.624;P<0.05)。结论对IGT合并MS患者采用生活方式干预联合阿卡波糖治疗,更能有效控制病情,延缓并发症发生。
Objective To observe the effect of lifestyle intervention combined with acarbose on impaired glucose tolerance (IGT) and metabolic syndrome (MS). Methods 210 patients with IGT and MS were randomly divided into control group and treatment group from October 2010 to September 2011. Both groups were given lifestyle interventions including low-salt, low-fat and low-calorie diet, proper exercise, weight control, smoking cessation Drinking and psychological guidance, the treatment group with acarbose 50 mg, 3 times / d, the control group with vitamin C 100 mg, 3 times / d. The changes of body mass index (BMI), triglyceride (TG), fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 hPG) were observed before and after treatment for 12 weeks. Results After treatment, BMI, TG, FPG and 2 hPG in both groups were significantly decreased (t = 7.118,2.708,10.012,8.797 in control group; t = 8.948,4.053,10.662,9.852 in treatment group; all P <0.05 or 0.01). Compared with the control group, the indexes of BMI, TG, FPG and 2 hPG in the treatment group were significantly decreased after treatment (t = 2.894, 2.209, 9.675, 3.624; P <0.05). Conclusion IGT combined MS patients with lifestyle intervention combined with acarbose treatment, more effective control of the disease, delay the occurrence of complications.