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目的:了解重症医学科肺炎克雷伯菌的感染及其耐药性的变化趋势并进行分析,为临床治疗及院内感染的防治提供参考。方法:回顾我院重症医学科2012年1月至2014年12月肺炎克雷伯菌感染及药敏结果。结果:共分离出肺炎克雷伯菌404株,肺炎克雷伯菌占所有病原菌比例,2012年7.8%,2013年8.1%,2014年8.3%,呈增加趋势。产ESBLs肺炎克雷伯菌比例最高达38.04%,其对头孢曲松、头孢呋辛钠、头孢唑啉的耐药率高达97.2%、98.1%、98.9%,接近100%。结论:重症医学科的肺炎克雷伯菌的感染仍较重,耐药率高,耐药谱广,治疗难度大,需继续加强病区环境消毒,防治交叉感染,控制院内感染的发生和流行。
OBJECTIVE: To understand and analyze the trend of Klebsiella pneumoniae infection and its drug resistance in the department of critical care, and provide references for clinical treatment and prevention and treatment of nosocomial infections. Methods: Review of our hospital from January 2012 to December 2014 Klebsiella pneumoniae infection and drug susceptibility results. Results: A total of 404 strains of Klebsiella pneumoniae were isolated. Klebsiella pneumoniae accounted for 7.8% of all pathogens in 2012, 8.1% in 2013 and 8.3% in 2014, showing an increasing trend. The production of Klebsiella pneumoniae ESBLs up to 38.04%, its ceftriaxone, cefuroxime sodium, cefazolin resistance rates as high as 97.2%, 98.1%, 98.9%, close to 100%. Conclusion: Klebsiella pneumoniae infection is still heavy in severe medical department, with high drug resistance rate, broad spectrum of drug resistance and difficult treatment. It is necessary to continue to strengthen the environmental disinfection of ward, prevent and control cross-infection and control the occurrence and prevalence of nosocomial infection .