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胰岛素抵抗是指靶器官对胰岛素的生理作用反应受损,包括糖、脂代谢及蛋白质合成、生长增殖等多方面的调节作用[l]。在细胞水平,胰岛素抵抗表明胰岛素信号传导发生障碍。临床上,胰岛索抵抗意味着需要高于生理水平的胰岛素才可能维持正常血糖稳态。胰岛素抵抗可导致多种疾病的发生,包括2型糖尿病、多囊卵巢综合征、非酒精性脂肪肝、代谢综合征等一系列急剧增加的与心血.管风险有关的慢性流行病,还有一些少见遗传病如黑棘皮病、矮妖
Insulin resistance refers to the target organ impaired physiological response to insulin, including sugar, lipid metabolism and protein synthesis, growth and proliferation and many other regulatory role [1]. At the cellular level, insulin resistance indicates a malfunction of insulin signaling. Clinically, islet resistance means that insulin above physiological level is required to maintain normal glucose homeostasis. Insulin resistance can lead to a number of diseases including type 2 diabetes, polycystic ovary syndrome, non-alcoholic fatty liver disease, metabolic syndrome and a series of dramatically increased cardiovascular risk-related chronic diseases, and some Rare genetic diseases such as acanthosis nigricans, Lilu demon