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目的探讨苏州地区老年2型糖尿病患者体内血清维生素D(vitamin D,VD)水平的分布状况及其与血糖控制效果的关系。方法 2013年7月—2014年6月随机抽取老年2型糖尿病患者152例,采用化学发光法测定所有患者血清25-羟维生素D3[25-hydroxyvitamin D3,25-(OH)-VD3],收集人口统计学、生活方式和实验室检验资料。根据国际通用分类标准将血清VD水平分为4组,分别为0~10、10~20、20~30、≥30 ng/ml,采用方差分析和Spearman秩相关分析比较血清VD水平与血糖控制效果的关系。结果老年2型糖尿病患者体内血清VD水平中位数为15.95(14.10,25.40)ng/ml,缺乏率为65.13%,男性患者的VD缺乏率较女性低,差异有统计学意义(P<0.05);男性血清VD水平为19.30(14.10,25.40)ng/ml,女性为15.40(12.10,21.40)ng/ml,比较差异有统计学意义(Z=32.076,P<0.05)。女性GSP与血清VD水平呈正相关(r=0.215,P<0.05)。结论老年2型糖尿病患者存在VD缺乏,且女性较男性缺乏情况更严重;血清VD水平可能与血糖控制效果有关,补充VD可能成为糖尿病治疗手段之一。
Objective To investigate the distribution of serum vitamin D (VD) in elderly patients with type 2 diabetes mellitus in Suzhou and its relationship with glycemic control. Methods A total of 152 elderly patients with type 2 diabetes mellitus were selected from July 2013 to June 2014. Chemiluminescence was used to determine the serum 25-hydroxyvitamin D3 (25- (OH) -VD3) Statistics, lifestyle and laboratory test data. Serum VD levels were divided into 4 groups according to the international classification standards, which were 0 to 10, 10 to 20, 20 to 30, and 30 ng / ml respectively. The level of serum VD and the effect of glycemic control were compared by ANOVA and Spearman rank correlation analysis Relationship. Results The median serum VD level in elderly patients with type 2 diabetes was 15.95 (14.10,25.40) ng / ml, the lack rate was 65.13%. The VD deficiency rate in male patients was lower than that in women (P <0.05) ; The level of serum VD in male was 19.30 (14.10,25.40) ng / ml and in female was 15.40 (12.10,21.40) ng / ml, the difference was statistically significant (Z = 32.076, P <0.05). Female GSP and serum VD levels were positively correlated (r = 0.215, P <0.05). Conclusion There is VD deficiency in elderly patients with type 2 diabetes, and women are more severely deprived of men than men. Serum VD levels may be related to the effect of blood sugar control. Supplementing VD may be one of the means of diabetes treatment.