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我们选择250例原发性肾病综合征(PNS),男182例,女68例,年龄平均26.9±13.1岁。根据临床表现不同将其分为Ⅰ型和Ⅱ型。Ⅱ型中又分为五组:(1)血尿组;(2)高血压组;(3)肾功能损害组;(4)尿FDP、C_3阳性组;(5)混合组。全部病例均用强的松治疗,首始治疗1mg.kg~(-1)/d,晨一次顿服,共6～8周,以后逐渐减量至5～10mg/d维持治疗,总疗程1年半到2年。71例加用环磷酰胺治疗,总量6～8g。64例采用过大剂量皮质激素的冲击治疗(即地塞米松60/d或甲基强的松龙0.5～1.0g/d,连用3天为一个疗程,平均用2～3个疗程)。
We choose 250 cases of primary nephrotic syndrome (PNS), 182 males and 68 females, mean age 26.9 ± 13.1 years old. According to different clinical manifestations will be divided into Ⅰ and Ⅱ type. Ⅱ type is divided into five groups: (1) hematuria group; (2) hypertension group; (3) renal dysfunction group; (4) urine FDP, C_3 positive group; All patients were treated with prednisone, the first treatment of 1mg.kg ~ (-1) / d, morning meal service, a total of 6 to 8 weeks, and then gradually reduced to 5 ~ 10mg / d maintenance treatment, the total course of treatment 1 Half a year to two years. 71 cases plus cyclophosphamide treatment, a total of 6 ~ 8g. Sixty-four patients were treated with a large dose of corticosteroid (ie, dexamethasone 60 / d or methylprednisolone 0.5-1.0 g / d for 3 days for one course of treatment, on average 2 to 3 courses of treatment).