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目的评价孕前优生检查和健康教育对出生缺陷干预的效果。方法通过计算机检索中国(CNKI)学术文献总库、万方数据知识服务平台、中文科技期刊数据库和中国生物医学文献数据库和人工检索的方式,收集2000-2014年公开发表的关于孕前优生检查和健康教育对出生缺陷干预的文章。对符合纳入标准的文章,应用Meta分析。结果最后符合纳入标准的文献共7篇,具有同质性,采用固定效应模型,效应合并值的假设检验Z=5.15,P<0.000 01,合并的OR值为0.34,差异有统计学意义。结论观察组出生缺陷率低于对照组,干预有效。
Objective To evaluate the effect of prenatal checkup and health education intervention on birth defects. Methods The computerized Chinese medicine retrieval database (CNKI), Wanfang Data Knowledge Service Platform, Chinese Science and Technology Periodicals Database, Chinese Biomedical Literature Database and manual retrieval methods were used to collect the published information about prenatal checkup and health checkup in 2000-2014 Education Articles on Interventions for Birth Defects. Meta-analysis was applied to articles that met the inclusion criteria. Results Finally, seven articles were included in the inclusion criteria, with homogeneity. Using the fixed effect model, the hypothesis test of effect consolidation value was Z = 5.15, P <0.000 01, and the combined OR was 0.34 with significant difference. Conclusion The birth defect rate in the observation group was lower than that in the control group, and the intervention was effective.