特异的甾体抗雌激素和抗孕激素的发现是甾体化学和甾体生物学研究领域中的重大突破,为甾体雌孕激素受体作用机理的深入研究及抗雌激素、抗孕激素在临床治疗方面的应用开辟了广阔前景。本文对特异的甾体抗雌激素、抗孕激素的发现、合成、构效关系、作用机理及应用等作一简要介绍。 The discovery of specific steroidal anti-estrogens and antiprogestins is a major breakthrough in the field of steroidal and steroidal biological studies, as well as in-depth studies on the mechanism of action of steroidal estrogen and progesterone receptors and antiestrogen, antiprogestin The application of clinical treatment has opened up broad prospects. This article gives a brief introduction of the specific steroidal anti-estrogen, anti-progesterone discovery, synthesis, structure-activity relationship, mechanism of action and application.