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本文用放免法测定了胃液中前列腺素Ｅ２（ＰＧＥ２）、血栓素Ｂ２（ＴＸＢ２），观察了十二指肠球部溃疡组（球溃组）、对照组ＰＧＥ２、ＴＸＢ２的含量以及胃粘膜血流量（ＧＭＢＦ）、跨粘膜电位（ＰＤ）等。球溃组ＰＧＥ２的含量明显低于对照组（Ｐ＜０．０１），ＧＭＢＦ、ＰＤ亦如此，ＴＸＢ２则相反。已经知道，ＰＧＥ２具有粘膜保护及抑制胃酸分泌的作用，结果表明，球溃的产生可能与ＰＧＥ２缺乏密切相关，至于ＴＸＢ２，可能是活动期溃疡周围炎症反应所致。
In this paper, the content of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) in gastric juice was measured by radioimmunoassay, and the content of PGE2, TXB2 and gastric mucosal blood flow were observed in duodenal ulcer group (GMBF), transmucosal potential (PD) and the like. The content of PGE2 in the ball ulcer group was significantly lower than that in the control group (P <0.01), as did GMBF and PD, and TXB2 was the opposite. It is known that PGE2 has the function of mucosal protection and inhibition of gastric acid secretion. The results show that the occurrence of ball ulcer may be closely related to the lack of PGE2, and TXB2 may be caused by the inflammatory reaction around active ulcers.