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目的测定中国维持性血液透析(maintenance hemodialysis,MHD)患者体内维生素K含量。方法选择2016年3月1日—30日接受规律血液透析治疗的18岁以上MHD患者作为MHD组,接受常规体检的健康受试者作为对照组。收集受试者的基本信息与生物化学检验结果。采集空腹血清标本,测定已知维生素K依赖性蛋白,即基质Gla蛋白(matrix gla protein,MGP)、骨钙蛋白(osteocalcin,OC)和未羧化骨钙蛋白(uncarboxylated osteocalcin,uc OC)。计算uc OC占OC的百分比(%uc OC)作为维生素K缺乏的替代指标,并分析上述参数的组间差异。结果 MHD组由70例MHD患者组成,对照组由70名健康受试者组成。两组的MGP比较差异无统计学意义[MHD组为(4.1±2.2)pg/m L,对照组为(4.4±1.0)pg/m L,P=0.441)]。MHD组的%uc OC显著高于对照组[MHD组为(79.3±19.3)%,对照组为(51.9±13.0)%,P<0.001]。结论中国MHD患者人群中普遍存在维生素K缺乏,除疾病原因外,推测饮食习惯亦有重要影响。
Objective To determine the content of vitamin K in Chinese patients with maintenance hemodialysis (MHD). Methods MHD patients and healthy subjects undergoing routine hemodialysis were enrolled in this study. METHODS: Healthy subjects aged 18 and over who received regular hemodialysis from March 1 to March 30 were selected as control group. Collect subjects’ basic information and biochemical test results. Fasting serum samples were collected for determination of known vitamin K-dependent proteins, namely matrix gla protein (MGP), osteocalcin (OC) and uncarboxylated osteocalcin (ucOC). The percentage of uc OC to OC (% uc OC) was calculated as a surrogate marker of vitamin K deficiency and the differences between the groups were analyzed. Results The MHD group consisted of 70 MHD patients and the control group consisted of 70 healthy subjects. There was no significant difference in MGP between the two groups (4.1 ± 2.2 pg / m L in MHD group and 4.4 ± 1.0 pg / m L in control group, P = 0.441). The% uc OC in MHD group was significantly higher than that in control group [(79.3 ± 19.3)% in MHD group and (51.9 ± 13.0)% in control group, P <0.001]. Conclusion The prevalence of vitamin K deficiency in Chinese population of MHD patients, in addition to the cause of the disease, speculated that eating habits also have an important impact.