研究了第4代头孢菌素的关键中间体7位侧链酸-氨噻二唑肟乙酸衍生物的合成工艺.考察了多种催化剂在不同浓度条件下对水解反应的影响,结果表明适宜的水解反应催化剂为LiOH,同时使用氧化剂和相转移催化剂可使收率大幅提高,收率达到80%,产品纯度可达97%,质量明显优于其他方法.本工艺原料易得,操作简单,收率提高,产品质量优异,适合工业化生产.“,”The synthesis process of ammonia thiadiazole oxime acetic acid,the fourth-generation cephalosporins key intermediate 7 side chain acid was studied. The variety of catalyst under the condition of different concentrations on the influence of the hydrolysis reaction were examined. The results showed that a suitable hydrolysis catalyst was LiOH,using both oxidant and a phase transfer catalyst could get yield a substantial increase,yield of 80%,purity of 97%,quality was superior to other methods. This process had the chanacteristics of readily available raw materials,simple operation,improving the yield,excellent product quality and being suitable for industrial production.