肾纤维化是在各种致病因子如炎症、损伤等作用下,肾间质细胞及细胞间质增多,尤其是基质蛋白合成增加,基质降解受抑制而造成细胞外基质的大量堆积导致肾小球硬化、小管间质纤维化和肾内血管硬化。而肾小管间质纤维化是肾脏疾病进展到终末期肾功能衰竭的最终共同通道。目前认为各 Renal fibrosis is caused by a variety of pathogenic factors such as inflammation, injury and other effects, increased interstitial cells and interstitial cells, especially increased matrix protein synthesis, inhibition of matrix degradation caused by a large accumulation of extracellular matrix resulting in small Sclerosis, tubulointerstitial fibrosis and intrarenal vascular sclerosis. Tubulointerstitial fibrosis is the ultimate common pathway for the progression of renal disease to end-stage renal failure. At present think each