Background The survival rate of preterm infants with critical congenital heart disease (P-CCHD) has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for short-term outcomes of P-CCHD and to evaluate risk factors associated with the outcomes. Methods Sixty-four PCCHD patients admitted to Guangdong General Hospital between 2011 and 2015 were included in this study. Demographic characteristics and patient records were reviewed. Logistic regression was used to analyze the risk factors of P - CCHD outcome. Results Thirty - six patients underwent surgical treatments for cardiac anomalies. Moreover, 31.25％ of the P - CCHD infants did not receive surgery because these parents refused further treatment. The in-hospital mortality rate was 8.3％ for the patients who underwent surgeries. During a median followup of 1.2 years, the survivors were basically healthy. However, mental and physical growth retardation remained. Conclusions Compared to infants in developed Weste countries, the treatments and short-term outcomes of PCCHD infants were satisfactory. However, the long-term outcomes remain to be determined.