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目的观察美托洛尔治疗扩张型心肌病心力衰竭患者的疗效。方法将65例扩张型心肌病并出现心力衰竭患者随机分为A、B两组。两组基本用药类同,均应用血管紧张素转化酶抑制剂、利尿剂和洋地黄制剂。A组在此基础上加用美托洛尔。定期门诊随访,观察治疗前后临床心功能NYHA分级,超声心动图检查等项目。结果A组与B组比较,治疗后美托洛尔组左室舒张末期内径和左室收缩末期内径分别为(54.6±6.7)mm和(38.7±3.9)mm,显著低于常规治疗组(56.5±6.8)mm和(39.9±4.6)mm;左室射血分数为(38.6±3.1)%,显著高于常规治疗组(34.1±2.7)%,P<0.01。心功能改善(P<0.05),病情恶化减少(P<0.05)。结论扩张型心肌病心力衰竭患者长期服用美托洛尔可使心功能改善。
Objective To observe the efficacy of metoprolol in patients with heart failure due to dilated cardiomyopathy. Methods Sixty-five patients with dilated cardiomyopathy and heart failure were randomly divided into A and B groups. Two groups of the same basic drugs, are used angiotensin converting enzyme inhibitors, diuretics and digitalis preparations. A group on this basis with metoprolol. Regular outpatient follow-up, observation of clinical cardiac function NYHA classification, echocardiography and other items. Results Compared with group B, the mean left ventricular end-diastolic diameter and left ventricular end-systolic diameter in metoprolol group were (54.6 ± 6.7) mm and (38.7 ± 3.9) mm, respectively, which were significantly lower than those in the conventional treatment group (56.5 ± 6.8 mm and 39.9 ± 4.6 mm respectively. The ejection fraction of left ventricle was (38.6 ± 3.1)%, which was significantly higher than that of the conventional treatment group (34.1 ± 2.7%), P <0.01. Heart function improved (P <0.05), the deterioration of the disease decreased (P <0.05). Conclusion Long-term use of metoprolol in patients with dilated cardiomyopathy heart failure improves cardiac function.