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目的：短期观察氯沙坦（科素亚）对糖尿病肾病（ＤＮ）患者尿蛋白的排泄和肾功能的影响。方法：５０例糖尿病肾病患者在抗糖尿病基础上，加科素亚 ５０－ １００ｍｇ／ｄ，短期观察 １０－１２周。结果：１０－ １２周后，２４尿总蛋白、尿白蛋白及ＩｇＧ排泄明显降低，Ｐ＜０．０５；平均动脉压明显下降（Ｐ＜０．０５），但尿蛋白排泄的降低与血压的下降无显著相关；血Ｃｒ、ＢＵＮ、血钾、空腹血糖和２４ｈ尿糖无明显变化。结论：科素亚对临床ＤＮ有较好的保护作用。
OBJECTIVE: To short-term observe the effects of losartan on urine protein excretion and renal function in patients with diabetic nephropathy (DN). Methods: 50 diabetic patients with diabetic nephropathy on the basis of anti-diabetes, co-coated with 50- 100mg / d, short-term observation of 10-12 weeks. Results: After 10 to 12 weeks, 24 urinary total protein, urinary albumin and IgG excretion were significantly decreased, P <0.05; mean arterial pressure significantly decreased (P <0.05), but decreased urinary protein excretion and blood pressure There was no significant correlation between serum Cr, BUN, serum potassium, fasting plasma glucose and 24h urinary glucose. CONCLUSION: Cozaar has a good protective effect on clinical DN.