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目的探讨短期胰岛素泵强化治疗对新诊断2型糖尿病胰岛β细胞功能的临床疗效。方法选取新诊断2型糖尿病患者102例,采用随机数字表法分成观察组和对照组,每组51例。对照组给予常规治疗,观察组给予短期胰岛素泵强化治疗,对比两组临床疗效。结果治疗后,观察组空腹C肽、餐后2 h C肽、餐后2 h血糖(2h PG)、胰岛β细胞功能(HOMA-β)及总胆固醇(AG)、三酰甘油(TG)水平与对照组比较差异均有统计学意义(P<0.05),胰岛素抵抗与对照组比较差异未见统计学意义(P>0.05)。结论短期胰岛素泵强化治疗新诊断2型糖尿病患者,可显著改善其血糖、胰岛素功能指标,对于血脂调节也具有一定临床价值。
Objective To investigate the clinical effect of short-term insulin pump intensive therapy on newly diagnosed pancreatic β-cell function in type 2 diabetes mellitus. Methods A total of 102 newly diagnosed type 2 diabetic patients were selected and randomly divided into observation group and control group with 51 cases in each group. The control group was given routine treatment, and the observation group was given short-term insulin pump intensive treatment, comparing the clinical curative effect of the two groups. Results After treatment, fasting C-peptide, postprandial 2-h C peptide, postprandial 2-h PG, HOMA-β and AG, triglyceride Compared with the control group, the differences were statistically significant (P <0.05), insulin resistance and the control group showed no significant difference (P> 0.05). Conclusion Short-term insulin pump intensive treatment of newly diagnosed type 2 diabetic patients can significantly improve its blood glucose, insulin function index, also has some clinical value for lipid regulation.