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慢性粒细胞型白血病(以下简称慢粒)是白血病中常见的一种类型.在我国约占全部白血病的18～20％。以青壮年者为多。自1953年以马利兰治疗本病以来,虽缓解率有所提高,但一般病程仍仅3～4年。近些年来又有二溴甘露醇、羟基脲等药物问世,我国医科院血研所研究证实中药青黛对慢粒有良好效果,而慢粒病人的生存期仍未见有明显延长。与急性白血病研究的显著进展相比,慢粒治疗进展缓慢。六十年代以来,脾切除又被提出作为延缓慢粒病人急变、延长生存期的治疗手段。国外虽已有不少报导,但结果尚不一致,治疗价值尚难肯定,国内仅见个例报告。为探讨慢粒病人脾脏切除手术的疗效,我们于1977年3月至1980年2月对12例慢粒病人进行了脾切除。现将有关情况报告如下,並结合文献加以讨论。一、手术指征本组病例手术指征有二:
Chronic myeloid leukemia (hereinafter referred to as CML) is a common type of leukemia, accounting for about 18 to 20% of all leukemia in our country. To young adults as much. Since 1953 with Maryland treatment of the disease, although the remission rate has improved, but the general course of disease is still only 3 to 4 years. In recent years, there are dibromomanitol, hydroxyurea and other drugs come out, the Chinese Medical Research Institute of Blood Institute confirmed that Chinese medicine indigo has a good effect on CML, and the survival of patients with chronic grain has not been significantly prolonged. CML progresses slowly compared to the dramatic progression of acute leukemia. Since the 1960s, splenectomy has also been proposed as a treatment for delaying the acute change and prolonging the survival of chronic myelogenous leukemia patients. Although there are many foreign reports, but the results are not consistent, the treatment is difficult to confirm the value of the domestic only see a case report. To investigate the efficacy of splenectomy in CML patients, we performed splenectomy on 12 CML patients from March 1977 to February 1980. The relevant information is reported below and discussed in the literature. First, surgical indications The surgical indications in this group there are two: