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雷公藤贴膏(每100cm~2贴膏含雷公藤乙酸乙酯提取物153mg、102mg)能明显抑制小鼠碳粒廓清率,减弱小鼠迟发型超敏反应,对抗小鼠血清溶血素的形成。此剂量下,给大鼠连续敷贴24h 或每天6h、连续12w 后均未见明显毒性反应;给家兔及人体皮肤敷贴每天12h,连续10d 均无刺激性;对豚鼠皮肤没有过敏反应出现。临床用于类风湿性关节炎病人疗效显著,能明显改善展僵、疼痛、压痛及肿胀等局部症状。
Tripterygium tsutsugamushi paste (every 100cm~2 patch containing 153mg, 102mg ethyl acetate extract of Tripterygium wilfordii) can significantly inhibit mice’s carbon clearance rate, attenuate delayed-type hypersensitivity in mice, and counteract mouse serum hemolysin formation. . At this dose, there was no obvious toxic reaction after continuous application for 24 hours or 6 hours per day for 12 hours in rats; for 12 hours per day for rabbits and human skin, no irritation was observed for 10 days; no allergic reaction to guinea pig skin occurred. . It is clinically effective for patients with rheumatoid arthritis and can significantly improve local symptoms such as stiffness, pain, tenderness, and swelling.