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[目的]观察养阴益肾颗粒联合地塞米松、氮芥、降纤酶治疗难治性肾病综合征疗效。[方法]将60例随机分为两组。治疗组30例长期口服养阴益肾颗粒;地塞米松、降纤酶静滴,氮芥静脉吸入。对照组30例泼尼松标准疗程。两组均西药常规对症治疗。治疗3疗程(治疗周期90d),随访半年判定疗效。[结果]血尿素氮、血肌酐、总胆固醇、血清总蛋白、血清白蛋白、尿蛋白定量等指标两组均有改善(P<0.01,P<0.05),总有效率及生化指标改善治疗组均优于对照组(P<0.01,P<0.05)。[结论]养阴益肾颗粒联合西药短程、冲击、循环治疗能有效控制难治性肾病综合征,值得进一步研究。
[Objective] To observe the therapeutic effect of Yangyin Yishen granule combined with dexamethasone, nitrogen mustard and defibrase on refractory nephrotic syndrome. [Methods] 60 cases were randomly divided into two groups. 30 cases of long-term oral treatment of yin and kidney tablets; dexamethasone, defibrase infusion, nitrogen mustard vein inhalation. Control group, 30 cases of prednisone standard course of treatment. Both groups were routine Western symptomatic treatment. Treatment of 3 courses (treatment cycle 90d), followed up for 6 months to determine the efficacy. [Results] The indexes of blood urea nitrogen, serum creatinine, total cholesterol, total serum protein, serum albumin and urinary protein in both groups were improved (P0.01, P0.05), and the total effective rate and biochemical indexes improved All were better than the control group (P <0.01, P <0.05). [Conclusion] Yang Yin Yishen granule combined with western medicine can effectively control refractory nephrotic syndrome by short-course, impact and cyclic treatment, which deserves further study.